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Monday, March 11, 2013

Woods stretches his lead on Blue Monster

Tiger Woods pumps his fist after making birdie putt on the 18th hole during the third round of the Cadillac Championship golf tournament Saturday, March 9, 2013, in Doral, Fla. (AP Photo/Alan Diaz)

Tiger Woods follows his shot from the eighth tee during the third round of the Cadillac Championship golf tournament on Saturday, March 9, 2013, in Doral, Fla. (AP Photo/Wilfredo Lee)

Tiger Woods bows his head in frustration after missing a putt for birdie on the ninth green as Graeme McDowell of Northern Ireland, gets ready to place his ball during the third round of the Cadillac Championship golf tournament Saturday, March 9, 2013, in Doral, Fla. (AP Photo/Alan Diaz)

Graeme McDowell, of Northern Ireland, celebrates after making eagle on the 16th hole during the third round of the Cadillac Championship golf tournament, Saturday, March 9, 2013 in Doral, Fla. (AP Photo/Wilfredo Lee)

Phil Mickelson hits out of a sand trap on the 16th hole during the third round of the Cadillac Championship golf tournament, Saturday, March 9, 2013 in Doral, Fla. (AP Photo/Wilfredo Lee)

DORAL, Fla. (AP) ? With one last birdie putt that never looked like it was going anywhere but in the hole, Tiger Woods walked off the Blue Monster in a familiar position.

He had a four-shot lead over Graeme McDowell in the Cadillac Championship, the 17th time on the PGA Tour that he has led by at least four shots going into the final round. Woods has never lost when leading by that much on tour.

Saturday at Doral was a reminder, however, how quickly it all can change.

Woods knocked in a short birdie putt on the 15th hole to put six shots between him and McDowell.

Two holes later, after McDowell chipped in for eagle and Woods found himself staring some 20 feet in the air at his golf ball lodged in a palm tree to the right of the 17th fairway, the lead was cut in half.

Woods saved his best for the final hole.

He drilled a tee shot into the fairway, hit 9-iron to 15 feet and made his 24th birdie of the tournament for a 5-under 67, putting him on the cusp of another World Golf Championship and a big step toward returning to No. 1 in the world.

"After I made birdie on 15, I was looking pretty good with a six-shot lead, and with a drivable par 4," Woods said. "Two holes later, it's now cut down to three. I piped a tee shot down there, hit a little 9-iron there and was able to pour that putt in there."

The ball never came down from the tree, which was about the only thing that didn't fall his way.

The 24 birdies and 74 putts are personal records for Woods. More importantly, it put him in great position to win his 17th WGC title, and his first since 2009.

"He controlled every part of his game very well, very few loose shots," said McDowell, who did well to two-putt for par from 85 feet on the last hole for a 69 that at least kept him in final group for Sunday.

"You know, 17 was a really bad break for him. But in true Tiger fashion that we've become very accustomed to over the years, to come back and birdie the last, he was fantastic today," he said.

"So maximum respect there. He's going to be a tough man to catch tomorrow. I get to watch it and get to see him, and hopefully get a chance to get close to him tomorrow."

Woods has a 39-2 record when he has the outright lead going into the final round on the PGA Tour. The only time he has ever lost a lead of more than two shots in any tournament around the world was in 2010 against an 18-man field at the Chevron World Challenge, when McDowell beat him in a playoff.

McDowell certainly was up for the fight on a breezy, sunny afternoon near Miami. Despite a shaky stretch of holes that appeared to end his chances, he drove just over the green on the par-4 16th and chipped in for eagle, and hit that putt across the 18th green that amazed even Woods.

"He hit a hell of a putt," Woods said.

Woods was at 18-under 198.

Phil Mickelson, who badly wanted to get into the final group, overcame a three-putt from 4 feet for double bogey on the third hole by making four birdies the rest of the way. He had a 69, along with Steve Stricker, and both were five shots behind.

"I threw away five or six shots on the greens and around the greens, and I feel like I don't have to play too much different," Mickelson said. "I just can't afford to give away those shots. I'm going to have to play a round like I played at Pebble last year, something in the low 60s."

A year ago, Mickelson shot 64 in the final round to win at Pebble Beach while playing in the same group with Woods.

Rory McIlroy, the world's No. 1 player, had a rough start until rallying on the back nine with five birdies in a six-hole stretch that carried him to a 71. He was 15 shots behind.

Woods used to own these WGC events, winning 16 of the first 30 that he played. He has gone 0-for-10 since Firestone in August 2009, though the odds were stacked in his favor at the Cadillac Championship. He already is a three-time winner at Doral, and he has been putting well ever since Stricker gave him a tip on the eve of the tournament.

"You know what kind of closer he is," Stricker said. "When he gets the lead in a golf tournament, it's tough. He doesn't let too many guys in usually when he gets the lead. We've all got our work cut out for us. We're going to have to go out and try to make birdies on a difficult golf course, which is hard to do."

It's even tougher with Woods playing like this. He has matched the low round of the tournament all three days.

For nine holes, McDowell threw his best golf at Woods, and Woods counterpunched in a magnificent display on the breezy Blue Monster.

McDowell opened with a 20-foot eagle, Woods with back-to-back birdies. McDowell hit his approach to 10 feet on the third hole, and Woods followed with a shot 6 inches inside as both made birdie.

McDowell finally tied him for the lead with a 20-foot putt on the sixth hole, and he had a 10-foot birdie attempt on the seventh for the outright lead. The stroke was tentative, and the ball dipped on the low side.

And that was as close as McDowell could get.

Woods had a one-shot lead as they walked toward the green on the par-5 10th hole, with McDowell on the green in two and poised to catch him again.

It all turned so suddenly.

Woods hit another superb wedge to 6 feet for birdie, while McDowell's eagle attempt slid 4 feet by the cup, and he missed it coming back for par. McDowell was furious, slapping his leg in disgust. McDowell and Woods each had 6 feet for par on the 11th ? Woods made, McDowell missed, his first bogey of the week.

That gave Woods a three-shot lead, and McDowell fell even further behind when he muffed a pitch behind the 14th green and took double bogey, and Woods hit a towering tee shot on the par-3 15th to 6 feet for birdie.

"The three-putt on 10 kind of rattled me a little bit, because Tiger didn't look like he was going to do anything wrong," McDowell said. "I really felt like I needed to be making putts like that."

McDowell at least stayed in the game, but after his putt across the length of the 18th green stopped inside a foot from the hole, he could only watch as Woods poured in another putt for yet another birdie, making the task on Sunday even more difficult.

The leaderboard still had the best golfers. Woods, however, separated himself from them.

Honda Classic winner Michael Thompson and Sergio Garcia each had a 67 and were at 11-under 205, along with Charl Schwartzel (69) and Keegan Bradley (69). Masters champion Bubba Watson could only manage a 71 and was eight shots behind.

Woods will be going for his second win of the year, an ominous sign with the Masters a month away. Woods has not won twice before the Masters in five years.

"All respect to the way he handled himself today and the way he played," McDowell said. "He's going to be a tough guy to catch. But according to the forecast tomorrow, we are going to have strong winds. I think that's an advantage to the rest of the field. ... With tough conditions tomorrow, hopefully we'll have a chance."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-03-10-GLF-Cadillac-Championship/id-a349a5998e6b4328b9b17394f1323f2e

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Tuesday, February 26, 2013

Rape Of Adopted Ohio Kids Unusual, Haunting Case - KHQ Right Now

TROY, Ohio (AP) - The one-story, brick ranch-style home blends into the working-class neighborhood along Nutmeg Square in this western Ohio city, offering no signs of the terrible secrets it once concealed.

Its former owner will return to court in Dayton on Tuesday to be sentenced for guilty pleas to child rape and related charges in a haunting case that experts call unusual because the perpetrator was an adoptive father and the victims were three boys in his care. The pleas have all but ensured he will spend the rest of his life in prison.

The 40-year-old man, whom The Associated Press isn't naming to protect the children's identities, said in an interview that he had been a foster parent, youth basketball coach and substitute teacher for years without any problems. He said he didn't adopt the boys with bad intentions.

"I always wanted to protect kids," he said during one of two interviews at the Miami County Jail. "Somewhere along the line, things went wrong."

In an era of stunning cases of sexual abuse of young boys by respected authority figures ? priests, Boy Scout leaders, an assistant coach at a famed college football program ? the repeated rapes of boys by an adoptive father who also arranged for two other men to rape one adopted son shocked his unsuspecting neighbors, investigators and children's services officials.

"It was just devastating to hear about. It's really sad for the kids," said April Long, a mother of three who was their next-door neighbor. She and other neighbors say they didn't suspect anything; the children played outside, and the man did neighborly things like pick up their mail or mow their lawn when they were away.

"You think: 'What could I have done? Is there something we missed that we should have seen?'" Long said, gazing at the home from her front porch lined with children's bicycles.

The single man was a foster parent for six other children before he began adopting children in the past three years. He adopted a brother and sister and an unrelated boy, and was in the process of adopting another boy, all ages 9 to 12, when authorities arrested him a year ago Sunday following an undercover sting that began when a detective looked into an online posting about "taboo sex."

Ohio officials don't believe there has been a comparable case in the state in recent years, and media reports over the past five years show only a handful of reported cases nationally in which adoptive fathers sexually abused children in their care. Child abuse by adoptive fathers is much rarer than by biological fathers, or by other male relatives and non-relatives, federal studies have indicated.

"This isn't a typical situation. It certainly isn't typical of people seeking adoption," said David Finkelhor, director of the Crimes Against Children Research Center at the University of New Hampshire. "Most abusers of this sort have an interest in a child during a certain period of their development. They are looking for opportunities where they can get access to the kids. They don't want to have custodial responsibility."

Fostering and adopting children meant passing background checks and other scrutiny, with home studies and follow-up visits by social workers.

"There can be terrible, horrific instances that no one at any level of government or the adoption system foresaw," Benjamin Johnson, spokesman for the Ohio Department of Job and Family Services, said of the case. "That can be a very difficult thing to reconcile ... and we think about that a lot."

The private adoption agency, Dayton-based Action Inc., has said little about the case other than to deny wrongdoing. The state reviewed its operations and noted some procedural violations but no reason to suspend or revoke the agency's license. All the children had been in Texas foster care before coming to Ohio through the agency, one of many that work through interstate agreements to find homes for some of the more than 100,000 children in foster care awaiting adoption at any given time in the United States.

The adoptive father said the three children appeared to be doing so well, he was asked by an agency employee to take a fourth.

The children were involved in sports, school and church and played with other children. They went trick-or-treating ? snapshots from two Halloweens ago show the boys dressed as Green Lantern and Star Wars' Darth Maul and the girl as a princess. They had Xboxes, Wiis and other games and toys at home.

"I loved my kids and wanted the best for them," the man said.

He said he had been sexually abused as a child by a close family member and blames that for his feeling that he wasn't doing anything wrong when he began taking the boys into his bed in what he claimed was a way of showing love.

"I never forced the boys to do anything," he said. "That might not mean anything to anyone else, but it's important to me."

But his explanation doesn't account for subsequently inviting a man to their Troy home to rape one of the boys, and then taking the same boy to another man's home to be raped. He agreed that was wrong, although he stressed that he didn't prostitute the boy by getting anything in return.

Apparently, no child ever hinted at any problem when separated from him by case workers for interviews.

"I guess they just liked it there," the man said.

Police reported that when they interviewed the boy, then age 10, who had also been raped by the two other men, he began shaking, after initially refusing to confirm that anything wrong had happened.

He told police he "didn't want to be taken from this home and separated from his new brothers and sister," a police report stated.

After the man was arrested, the 9-year-old boy who hadn't been adopted yet was returned to Texas social services authorities, while the other three were placed in foster care in Ohio.

At a pretrial hearing last November, a child psychologist testified about some three dozen therapy sessions he had had with the 10-year-old boy, the Dayton Daily News reported.

"It is so traumatic within the security of my office, when he's laying on a sofa, hugging a bear, to talk about these things," said Gregory Ramey of The Children's Medical Center of Dayton.

The adoptive father has already been sentenced here to at least 60 years in prison. In Dayton, he is expected to be sentenced to at least 50 years, to run concurrently.

He said he agreed to plead guilty in hopes of sparing the children from having to testify, that it "was the last good thing I could do for them." In a jail interview, his eyes teared up and his voice choked as he said he was sorry for the pain he had caused them.

In a letter from jail, he wrote: "I've been able to protect my kids from everything and everyone, except myself."

Source: http://www.khq.com/story/21327751/rape-of-adopted-ohio-kids-unusual-haunting-case

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U-M study challenges notion of using Herceptin only for HER2-positive breast cancer

Public release date: 26-Feb-2013
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Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Breast cancer stem cells express HER2, even in 'negative' tumors, study finds

ANN ARBOR, Mich. New research from the University of Michigan Comprehensive Cancer Center finds that the protein HER2 plays a role even in breast cancers that would traditionally be categorized as HER2-negative and that the drug Herceptin, which targets HER2, may have an even greater role for treating breast cancer and preventing its spread.

About 20 percent of women with breast cancer have tumors labeled HER2-positive. And since the drug Herceptin has come on the scene, it has had a tremendous impact on survival for these women, particularly when it is given in the adjuvant setting, after surgery to remove the primary cancer. The new findings have potential implications for an additional 65 percent of women with breast cancer.

A recent study based on new analyses of old data found some tumors were incorrectly categorized as HER2-positive and as a result those women received adjuvant Herceptin. It turns out, they benefited as much from the treatment as woman with actual HER2-positive cancer.

"We now provide a molecular explanation for the surprising finding that adjuvant Herceptin benefited some women with HER2-negative breast cancer. If this is confirmed in clinical trials, it could alter our approach to breast cancer treatment," says study author Max S. Wicha, M.D., distinguished professor of oncology and director of the U-M Comprehensive Cancer Center.

At this point, patients with HER2-negative breast cancer are not advised to take Herceptin.

The explanation is that HER2 is selectively expressed in the cancer stem cells of many HER2-negative breast tumors. Because the stem cells represent such a small number of cells in a tumor, the amount of HER2 is not high enough to meet the threshold for a HER2-positive cancer.

The researchers had previously shown HER2 plays an important role in cancer stem cells the small number of cells in a tumor that fuel its growth and spread. These cells represent 1 percent to 5 percent of all the cells in a tumor. They are resistant to current chemotherapy and radiation treatments but since they express HER2, they are effectively targeted by Herceptin.

Further, the researchers in this new study found that for tumors classified as HER2-negative, HER2 levels were higher in bone metastases compared to the primary breast tumor. Bone is the most frequent site to which breast cancer spreads.

The researchers administered Herceptin to mice with these bone lesions and found that it was most effective when given early, when tumors were small or mere "micrometastases." In these cases, Herceptin almost completely blocked the tumors from growing. When the drug was given later, after tumors were established, it had little effect.

"We have shown that the bone microenvironment induces HER2 expression in these tumors. If Herceptin can target bone micrometastases, then administering it to patients before metastases develop could help reduce tumor recurrence," says study author Hasan Korkaya, Ph.D., research assistant professor of internal medicine at the U-M Medical School.

The implications of this finding are that we need cancer treatments that target the small number of cancer stem cells in addition to traditional chemotherapies that eliminate the bulk tumor cells. This means that merely looking at whether a tumor shrinks is not good enough to determine whether the treatment will have long term benefit.

"This work has very significant implications for how we have developed adjuvant therapies. The idea of using drugs that cause tumors to shrink, which has been the accepted paradigm for developing therapies, is flawed. Our work suggests that adjuvant therapies will need to target the cancer stem cell population. Eliminating cancer stem cells by effective adjuvant therapies should prevent tumor recurrence, ultimately resulting in more cures," Wicha says.

###

A large randomized clinical trial sponsored by the National Institutes of Health is currently open at U-M and other sites across the country to address this question. Patients whose tumors are not considered HER2-positive by classic testing should not receive Herceptin outside of this trial. For information about the trial, call the U-M Cancer AnswerLine at 800-865-1125.

Additional authors: Suthinee Ithimakin, Kathleen C. Day, Fayaz Malik, Qin Zen, Scott J. Dawsey, Tom F. Bersano-Begey, Ahmed A. Quraishi, Kathleen Woods Ignatoski, Stephanie Daignault, April Davis, Christopher L. Hall, Nallasivam Palanisamy, Amber N. Heath, Nader Tawakkol, Tahra K. Luther, Shawn G. Clouthier, Whitney A. Chadwick, Mark L. Day, Celina G. Kleer, Dafydd G. Thomas, Daniel F. Hayes

Funding: National Cancer Institute grants CA129765 and CA101860; Breast Cancer Research Foundation; Komen for the Cure; Taubman Institute at the University of Michigan; Fashion Footwear Charitable Foundation of New York/QVC Presents Shoes-On-Sale; Stand Up to Cancer grant SU2C-AACR DT0409

Disclosure: Max Wicha has financial holdings in OncoMed Pharmaceuticals, receives support from Dompe and MedImmune and serves on the scientific advisory board of Veristem; Hasan Korkaya receives research support from MedImmune; Daniel Hayes has received research support from Pfizer, Novartis and Veridex and holds stock options for his role on the scientific advisory board for OncImmune.

Reference: Cancer Research, published online Feb. 26, 2013

Resources:

U-M Cancer AnswerLine, 800-865-1125
U-M Comprehensive Cancer Center, www.mcancer.org
Clinical trials at U-M, www.UMClinicalStudies.org/cancer

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

U-M study challenges notion of using Herceptin only for HER2-positive breast cancer

Public release date: 26-Feb-2013
[ | E-mail |

Share ]

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Breast cancer stem cells express HER2, even in 'negative' tumors, study finds

At this point, patients with HER2-negative breast cancer are not advised to take Herceptin.

###

Reference: Cancer Research, published online Feb. 26, 2013

Resources:

U-M Cancer AnswerLine, 800-865-1125
U-M Comprehensive Cancer Center, www.mcancer.org
Clinical trials at U-M, www.UMClinicalStudies.org/cancer

[ | E-mail |

Share ]

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-02/uomh-usc022113.php

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Sunday, February 24, 2013

Best Buy Offers $100 Discount on Windows 8 Touchscreen PCs

Beginning Sunday, Best Buy will be offering a $100 discount on all touchscreen Windows 8 PCs. Best Buy sales of touchscreens has not been keeping up with national averages and hope to boost sales with the $100 discounted offer to consumers?.. and to make their customers happy of course.

The retailer said Friday it decided to launch the promotion after recent surveys the company conducted showed the consumers who bought touchscreen Windows 8 devices were significantly happier than those who bought PCs with a typical screen.

Comments

Posted by Al 4:12 PM (CST)??

Source: http://www.hardocp.com/news/2013/02/23/best_buy_offers_100_discount_on_windows_8_touchscreen_pcs/

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Google Is Making Moves To Seriously Disrupt Groupon (GRPN, GOOG)

Business Insider writes, Groupon's stock has been crawling back from the abyss, with the company now worth about $3.8 billion. That's still less than the $6 billion Google offered for the daily-deals site shortly before Groupon went public. And now Google seems like it's moving to kill off Groupon by making ads for discounts and deals easier than ever to buy. Larry Kim, founder and CTO of WordStream, an online-marketing technology company, noticed that Google's Offers ads?deals broadly similar to Groupon's email discounts?were now available to anyone using Google's upgraded AdWords dashboard for managing ads. Rob?

Continue reading Google Is Making Moves To Seriously Disrupt Groupon (GRPN, GOOG) at Business Insider

Source: http://technewstube.com/business-insider/175017/google-is-making-moves-to-seriously-disrupt-groupon-grpn-goog/

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