Largest genetic sequencing study of human disease

May 22, 2013 ? Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.

The exact cause of these diseases -- autoimmune thyroid disease, celiac disease, Crohn's disease, psoriasis, multiple sclerosis and type 1 diabetes- is unknown, but is believed to be a complex combination of genetic and environmental factors. In each disease only a proportion of the heritability is explained by the identified genetic variants. The techniques used to date, have generally identified common (in the population) variants of weak effect.

In this study, using high-throughput sequencing techniques,a global team of scientists sought to identify new variants, including rare and potentially high risk ones, in 25 previously identified risk genes in a sample of nearly 42,000 individuals (24,892 with autoimmune disease and 17,019 controls).

It has been suggested -- in the 'rare-variant synthetic genome-wide association hypothesis' -- that a small number of rare variants in risk genes are likely to be a major cause of the heritability of these conditions. However, the study published today in the journal Nature, suggests that the genetic risk of these diseases more likely involves a complex combination of hundreds of weak-effect variants which are each common in the population.

The authors estimate that rare variants in these risk genes account for only around three per cent of the heritability of these conditions that can be explained by common variants.

David van Heel, Professor of Gastrointestinal Genetics at Barts and The London School of Medicine and Dentistry at Queen Mary and director of the Barts and The London Genome Centre, led the study. He said: "These results suggests that risk for these autoimmune diseases is not due to a few high-risk genetic variations but seems rather due to a random selection from many common genetic variants which each have a weak effect.

"For each disease there are probably hundreds such variants and the genetic risk is likely to come from inheriting a large number of these variants from both parents. If this is the case then it may never be possible to accurately predict an individual's genetic risk of these common autoimmune diseases. However, the results do provide important information about the biological basis of these conditions and the pathways involved, which could lead to the identification new drug targets."

The research utilised high-throughput sequencing techniques performed at the Barts and The London Genome Centre and demonstrated for the first time that the sequencing can call genotypes as accurately as 'gold standard techniques' such as genotyping array platforms. Additional laboratory work was carried out at the Blizard institute at Queen Mary.

Professor Richard Trembath, Vice Principal and Executive Dean for Health at Barts and The London School of Medicine and Dentistry, Queen Mary, and a co-author on the paper said: "The results prompt a re-assessment of the genetic architecture that determines risk for development of common auto-immune disorders and will fuel future careful assessment of regions of the human genome beyond those presently known to confer susceptibility to these important medical conditions."

This study was primarily funded by the Medical Research Council with additional funding from Coeliac UK.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/YB1h5ioWbVo/130522131124.htm

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Daft Punkitecture Around The World

Daft Punk recently released this slick and stylish photo shoot set in a famous LA modernist house, though we here at Architizer think there?s more here than meets the eye. What other ?Daft Punkitecture? is out there in the world waiting to be found?

Read more...

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Rw3Tl-Qk9Ns/daft-punkitecture-around-the-world-509131149

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European Union Leaders Meet on Tax Avoidance

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Source: www.nytimes.com --- Wednesday, May 22, 2013
The forum was to focus on entities based in Europe, but it comes after the United States Senate found that Apple had reduced taxes by recording income in Ireland. ? ? ? ? ...

Source: http://www.nytimes.com/2013/05/23/business/global/european-union-leaders-meet-on-tax-avoidance.html?partner=rss&emc=rss

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Slow earthquakes: It's all in the rock mechanics

May 20, 2013 ? Earthquakes that last minutes rather than seconds are a relatively recent discovery, according to an international team of seismologists. Researchers have been aware of these slow earthquakes, only for the past five to 10 years because of new tools and new observations, but these tools may explain the triggering of some normal earthquakes and could help in earthquake prediction.

"New technology has shown us that faults do not just fail in a sudden earthquake or by stable creep," said Demian M. Saffer, professor of geoscience, Penn State. "We now know that earthquakes with anomalous low frequencies -- slow earthquakes -- and slow slip events that take weeks to occur exist."

These new observations have put a big wrinkle into our thinking about how faults work, according to the researchers who also include Chris Marone, professor of geosciences, Penn State; Matt J. Ikari, recent Ph.D. recipient, and Achim J. Kopf, former Penn State postdoctural fellow, both now at the University of Bremen, Germany. So far, no one has explained the processes that cause slow earthquakes.

The researchers thought that the behavior had to be related to the type of rock in the fault, believing that clay minerals are important in this slip behavior to see how the rocks reacted. Ikari performed laboratory experiments using natural samples from drilling done offshore of Japan in a place where slow earthquakes occur. The samples came from the Integrated Ocean Drilling Program, an international collaborative. The researchers reported their results recently in Nature Geoscience.

These samples are made up of ocean sediment that is mostly clay with a little quartz.

"Usually, when you shear clay-rich fault rocks in the laboratory in the way rocks are sheared in a fault, as the speed increases, the rocks become stronger and self arrests the movement," said Saffer. "Matt noticed another behavior. Initially the rocks reacted as expected, but these clays got weaker as they slid further. They initially became slightly stronger as the slip rate increased, but then, over the long run, they became weaker."

The laboratory experiments that produced the largest effect closely matched the velocity at which slow earthquakes occur in nature. The researchers also found that water content in the clays influenced how the shear occurred.

"From the physics of earthquake nucleation based on the laboratory experiments we would predict the size of the patch of fault that breaks at tens of meters," said Saffer. "The consistent result for the rates of slip and the velocity of slip in the lab are interesting. Lots of things point in the direction for this to be the solution."

The researchers worry about slow earthquakes because there is evidence that swarms of low frequency events can trigger large earthquake events. In Japan, a combination of broadband seismometers and global positioning system devices can monitor slow earthquakes.

For the Japanese and others in earthquake prone areas, a few days of foreknowledge of a potential earthquake hazard could be valuable and save lives.

For slow slip events, collecting natural samples for laboratory experiments is more difficult because the faults where these take place are very deep. Only off the north shore of New Zealand is there a fault that can be sampled. Saffer is currently working to arrange a drilling expedition to that fault.

The National Science Foundation and the Deutsche Forschungsgemeinschaft supported this work.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/8I4KmSqzd7g/130520114021.htm

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Where do you hold your cell phone? Your brain decides

Your gadgets

Nidhi Subbaraman NBC News

2 hours ago

Getty Images

Right-handed and left-brained?

When you talk on the cellphone, do you hold it up to your right ear or left?

A group of researchers at the Henry Ford Health System in Michigan suggest that how you hold your phone could give away the dominant half of your brain.

The lesson the group took away was this: Most right-handed people, who eat and write and throw with their right hand, also prefer to talk with their cellphone held up to their right ear. Left-handed people hold their phone to their left ear.

They explain their findings involving 717 subjects in the Journal of the American Medical Association's Head and Neck Surgery journal in May this year.

Of all the people who took an online survey, 90 percent were right-handed. And more than half of them ? 68 percent ? said they held their phone to their right ear. Among the left-handed phone holders (65 people in all) 72 percent said they held up their phone to their right ear.

There were some caveats: Some survey responders did note that their capable hand (rather than their listening ear) was what guided their cellphone holding habits ? right-handed folks did note that the device just felt more comfortable in their right hand. Also, people's natural cellphone handedness was thrown off if they had trouble hearing with one ear ? as you'd expect, they held the phone to the ear that worked.

Nidhi Subbaraman writes about technology and science. Follow her on Facebook, Twitter and Google+.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2c2993d4/l/0L0Stoday0N0Ctech0Cwhere0Edo0Eyou0Ehold0Eyour0Ecell0Ephone0Eyour0Ebrain0Edecides0E6C9996516/story01.htm

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Next-gen consoles ready to thrive, says Riccitiello - GamesIndustry.biz

Despite recent disruption in the gaming industry, former Electronic Arts CEO John Riccitiello thinks the next-gen consoles can excel even in a world of smartphones and tablets. In a guest column on Kotaku today, Riccitiello laid out what he sees as four potential stumbling blocks that, if avoided, will guarantee next-gen success for Microsoft and Sony.

Ricitiello's first point of emphasis was that the systems need to be aimed squarely at gamers. To reach the core audience, the new consoles shouldn't be positioned as all-in-one multimedia boxes.

"The risk is that either or both of the new platforms emphasize these 'value-add' experiences too much, both in the user interface on the consoles themselves, or in the story they tell consumers when they unleash their avalanche of advertising," Riccitiello said.

The second and third points were more about not repeating the mistakes of previous console launches. Specifically, Riccitiello said supply chains need to be improved such that anyone who wants a new console at launch can find one on shelves, and the end product needs to be priced low enough that consumers will snatch up all the systems produced.

Finally, Riccitiello said Microsoft and Sony need to tread lightly around "third-rail topics" like DRM and second-hand game sales. In his view, the solution is to make the console ecosystem more open, and less of a walled garden. If they play their cards right, Microsoft and Sony will actually find gamers will "learn to love" more connected console experiences, Riccitiello said.

"It needs to be simple, seamless and without a bunch of headaches with multiple registration, identity and pay gates," Riccitiello said. "The walled garden will fall eventually."

Source: http://www.gamesindustry.biz/articles/2013-05-20-next-gen-consoles-ready-to-thrive-says-riccitiello

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Link between childhood ADHD and obesity revealed in first long-term study

May 20, 2013 ? A new study conducted by researchers at the Child Study Center at NYU Langone Medical Center found men diagnosed as children with attention-deficit/hyperactivity disorder (ADHD) were twice as likely to be obese in a 33-year follow-up study compared to men who were not diagnosed with the condition.

The study appears in the May 20 online edition of Pediatrics.

"Few studies have focused on long-term outcomes for patients diagnosed with ADHD in childhood. In this study, we wanted to assess the health outcomes of children diagnosed with ADHD, focusing on obesity rates and Body Mass Index," said lead author Francisco Xavier Castellanos, MD, Brooke and Daniel Neidich Professor of Child and Adolescent Psychiatry, Child Study Center at NYU Langone. "Our results found that even when you control for other factors often associated with increased obesity rates such as socioeconomic status, men diagnosed with ADHD were at a significantly higher risk to suffer from high BMI and obesity as adults."

According to the Centers for Disease Control and Prevention, ADHD is one of the most common neurobehavioral disorders, often diagnosed in childhood and lasting into adulthood. People with ADHD typically have trouble paying attention, controlling impulsive behaviors and tend to be overly active. ADHD has an estimated worldwide prevalence of five percent, with men more likely to be diagnosed than women.

The prospective study included 207 white men diagnosed with ADHD at an average age of 8 and a comparison group of 178 men not diagnosed with childhood ADHD, who were matched for race, age, residence and social class. The average age at follow up was 41 years old. The study was designed to compare Body Mass Index (BMI) and obesity rates in grown men with and without childhood ADHD.

Results showed that, on average, men with childhood ADHD had significantly higher BMI (30.1 vs. 27.6) and obesity rates (41.1 percent vs. 21.6 percent) than men without childhood ADHD.

"The results of the study are concerning but not surprising to those who treat patients with ADHD. Lack of impulse control and poor planning skills are symptoms often associated with the condition and can lead to poor food choices and irregular eating habits," noted Dr. Castellanos. "This study emphasizes that children diagnosed with ADHD need to be monitored for long-term risk of obesity and taught healthy eating habits as they become teenagers and adults."

The research was supported by grants MH-18579 and T32 MH-067763 from the National Institute of Mental Health, grant DA-16979 from the National Institute on Drug Abuse and grant PIOF-253103 from the European Commission.

Co-authors of the study include Salvatore Mannuzza, PhD (retired); Samuele Cortese, MD, PhD, of the Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience and Verona University, Italy; Erika Proal, PhD, of the Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience and Neuroingenia, Mexico; Rachel G. Klein, PhD, and Maria A. Ramos Olazagasti, PhD, of the Child Study Center at NYU Langone Medical Center.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/F-Y48m4kXdo/130520113925.htm

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Wireless Communications and Networks | Mobile Phone | Wireless

Project Description:
Here are some enquiries which need to be solved for my office:

Enquiry 1:
By experimentation, work out the lowest SNR, under which 4 users can simultaneously communicate, without error, via this system. For SNR, simply report the largest value for the noise power parameter, in the spreadsheet cell which changes the strength of the noise. Your answer should include a report on experiments in which the messages could be repeatedly communicated successfully, and also reports of experiments in which communication sometimes failed.

Enquiry 2:
It has become established practice to define network security by means of rules. These rules can take many different forms. Although security is often concerned with preventing access, good security requires consideration of other aspects than merely preventing access. Rules may state what types of service or activity are not allowed, and also what should be allowed. Rules may take precedence over other rules.
Complete set of rules for the following situations:
(i) A network of wireless access which is provided in a nationwide network of hotels;
(ii) A university campus network (with three types of user ? academics, admin, and students);
(iii) A home wireless network.
In each case, include both positive and negative rules, and also rules which are not simply about access, and attempt to ensure that the resulting set of rules is unambiguous, complete, and consistent.

Criteria
? In Enquiry 1, the SNR at which communication can be achieved for all four sources, by codes, has been found.
? Evidence is provided that reliable communication can be conducted, using the given codes, with this level of noise.
? Evidence is provided that reliable communication cannot be conducted, using the given codes, when the noise is higher than this level.
? In Enquiry 2, a satisfactory set of rules has been provided for all three situations, including rules which describe what users can do, rules which describe what they can't do,
? The issue of how the identity of users should be managed has been addressed in the security rules.
? The issue of security rules for administration users has been addressed.
? The completeness and consistency of the rules has been satisfactorily discussed.

Skills required:
Mobile Phone, Wireless Additional Files: Enquiry+1.docx

Source: http://www.freelancer.com/projects/Wireless-Mobile-Phone/Wireless-Communications-Networks.html

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Brad DeLong : Department of "WTF?!?!": Education Gap Weblogging

Why oh why can't we have a better press corps?

For at least half a generation, liberals--at least liberals that I know--have been hammering on the fact that the stepping-away from the commitment to universal free or nearly-free education has been a long-run disaster for America. With Claudia Goldin and Larry Katz's The Race Between Education and Technology serving as its analytical spearhead, the liberals I know spend lots of time talking about how the pace of technological progress requires a more-educated and thus more-skilled workforce, and about how the rise in college costs starting around 1970 stopped the normal American pattern by which each generation gets much more education in its tracks--with rising income inequality between the 80th and the 20th percentile being a big consequences:

Solutions proposed vary from having your college costs be an income-contingent grant recaptured from those who earn much in life by a surcharge on your form 1040 to a mammoth federal commitment to universal access to broadband and to free provision of the highest-quality education online.

Some liberals (e.g., Larry Mishel of EPI) go further, and say that rising 80/20 inequality is the result not just of our losing the race between education and technology but also the collapse of labor unions. The Goldin-Katz alliance (or which I am a part) tends to see the collapse of the union movement as a consequence of the loss of the race.

Now comes Timothy Noah to tell me that none of this focus that I see among the liberals I talk to ever happened:

The 1 Percent Are Only Half the Problem: Most recent discussion about economic inequality in the United States has focused on the top 1 percent? that if we would just put a tight enough choke chain on the 1 percent, then we?d solve the problem of income inequality. But alas, that isn?t true, because it wouldn?t address the other half of the story: the rise of the educated class. Since 1979 the income gap between people with college or graduate degrees and people whose education ended in high school has grown?.

Conservatives don?t typically like to talk about income inequality. It stirs up uncomfortable questions about economic fairness?.

Liberals resist talking about the skills-based gap because they don?t want to tell the working classes that they?re losing ground because they didn?t study hard enough. Liberals prefer to focus on the 1 percent-based gap. Conceiving of inequality as something caused by the very richest people has obvious political appeal?

And it is at this point that I say: "WTF?!?!"

Now let me say that Timothy Noah is one of the very best of mainstream American journalists--he isn't an opinions-of-shape-of-earth-differ-both-liberals-and-conservatives-have-a-point clown uninterested in policy substance who covers our nation from a celebrity-gossip perspective.

But here we have, I think, another example of the Michael Kinsley-Clive Crook disorder: Noah provides no links to and no quotes from "liberals" who "resist talking about the skills-based gap because they don?t want to tell the working classes that they?re losing ground because they didn?t study hard enough". So he winds up just making stuff up--and the New York Times editorial process is sufficiently jelly-like that nobody asks him "who are you talking about?". This produces bad thought.

Indeed, read further down in the article and you find, near the end, links to Larry Mishel definitely not being resistant to talking about the decline of unions, to Josh Bivens not being resistant to talking about workers' reduced bargaining power and the 80/20 wage gap, Barack Obama and his staff worrying about the rising costs of college--in a story reported by Timothy Noah himself.

Are these people not liberals?

Source: http://delong.typepad.com/sdj/2013/05/department-of-wtf-education-gap-weblogging.html

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Rangers put Kinsler on DL, recall Profar

ARLINGTON, Texas (AP) ? The Texas Rangers have placed second baseman Ian Kinsler on the 15-day disabled list because of bruised ribs and recalled top prospect Jurickson Profar from Triple-A Round Rock.

The move was announced before the Rangers, with the best record in the majors, played their series finale against Detroit on Sunday night.

Because Kinsler entered Friday night's game as a pinch-runner, the DL move was retroactive to Saturday, when Kinsler didn't play. The earliest he would be eligible to return is June 2.

Kinsler is hitting .302 with seven home runs, 20 RBIs and 24 runs scored in 40 games.

Profar was hitting .278 at Round Rock, where he had an eight-game hitting streak. The 20-year-old Profar made his major league debut last season, hitting .176 in nine games.

Source: http://news.yahoo.com/rangers-put-kinsler-dl-recall-profar-213939909.html

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Cast AR hands-on with Jeri Ellsworth at Maker Faire 2013

When Valve's first hardware hire, Jeri Ellsworth, tweeted back in February that she was fired from the company, we were disappointed but also intrigued by what she meant by "time for new exciting projects." Well we finally saw what she's been up to here at at Maker Faire 2013. It's called Cast AR, and it's a pair of 3D augmented-reality glasses that she and former Valve programmer Rick Johnson were working on at Valve before they left.

The model we saw is still in the early prototype stages, but the concepts are already in place. Perched atop a pair of active shutter glasses are a couple of miniature LCD projectors, which bounce images from a connected computer onto a special reflective surface at a 120Hz refresh rate. A camera module sits on the eyewear's bridge and monitors an array of infrared LEDs embedded in the reflective surface. This allows for quick and accurate head tracking. Join us after the break for our impressions and stay tuned for our video interview with Jeri Ellsworth.

Gallery: Cast AR hands-on at Maker Faire 2013

Filed under: Gaming, Wearables

Comments

Source: http://www.engadget.com/2013/05/18/cast-ar-hands-on-with-jeri-ellsworth-at-maker-faire-2013/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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In Israel, a modern wall is halted by ancient terraces

Israel?s high court has issued an injunction against extending the separation barrier through the Palestinian village of Batir, famed for its 2,500-year-old terraces and aqueducts.

By Joshua Mitnick,?Correspondent / May 19, 2013

People run past the separation wall during the West Bank?s first marathon in Bethlehem, April 21, 2013.

Mahmoud Illean/AP

Enlarge

After scarring the ancient landscapes of Jerusalem and Bethlehem in the name of security, Israel?s separation barrier had been slated to carve through this Palestinian village?s 2,500-year old farm terraces and aqueducts.

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But for the first time in years, Israel?s high court has given Batir and its 6,000 residents ? famed for its annual yield of aubergines ??reason to hope that a way of life preserved through centuries won?t be destroyed.

Earlier this month Israel?s top justices issued a rare injunction against construction of the barrier, putting the onus on security authorities to demonstrate that it won?t risk Batir?s cultural and environmental heritage.

"Now I feel better because they avoid the idea [that would force] closure for our lands and destroy this heritage site," says Batir council head Akram Bader, standing alongside a gurgling spring which reputedly supplied water to Jerusalem during the era of the Roman empire. ?"Also, we have more supporters from both sides, from the Israeli, Palestinian, and all over the world."?

Indeed, the case of Batir is even more remarkable because, for the first time, an Israeli government agency came to the defense of the Palestinians affected by the barrier. A 13-page position paper by the Nature and Parks Authority declared that Batir actually represents a living vestige of a shared history dating back to the period of the second Jewish temple in Jerusalem.

The authority ? which flip-flopped its original position from 2005 when the barrier route through Batir was first proposed ? suggested the entire project should be stopped and rethought because it represented a response to a previous war rather than the future. The agricultural terraces of the Palestinian villages are among the most ancient in the world and are part of Jewish heritage because it is "a sign of the people of Israel in the Land of Israel."?

"It?s the first time that the government has spoken in two different voices,"? Gidon Bromberg, the Israeli director of the environmental group Friends of the Earth Middle East, told a group of reporters on a recent tour of the village. "We don?t want to see the demise of our neighbors' heritage because the bottom line is that it's something we all share."

Built into the terraced hillside, Batir?s vine-wrapped stone alleyways give way to the ancient Roman-era pools and tiny canals that run along pathways down to flood small earthen plots where eggplants grow. The villagers use stones to control the year-round flow of water, which is rotated daily among Batir?s eight main clans. The ancient method is far less lucrative that modern day drip agriculture, but villagers have stuck with tradition. ?

"We have learned to appreciate this cultural landscape. We have an interest in preserving these locations," says Yuval Peled, director of the park?s authority planning and development department. "In every place in the world these places are subsidized so it continues to function as in the past."

A decade ago, at the height of the Palestinian uprising, Israel?s government started construction on a controversial matrix of fences, walls, and security roads to block suicide bombers in the West Bank from reaching Israeli cities.

After an initial spurt of building that separated many Palestinians from their farming lands, the project has been creeping forward because of a tide of legal challenges to the barrier, a lack of funds, and the decline of the Palestinian uprising several years later.??

As of October 2012, only two-thirds of the planned 483-mile barrier had been completed, according to the Applied Research Institute - Jerusalem, a Palestinian environmental non-profit. Only in a handful of locations has the court intervened and forced the IDF to re-route.

The tens of thousands of acres of ancient terraces straddling the Green Line border in the Jerusalem hills stand as one of many reminders that the West Bank as a separate entity is a recent creation of the Arab-Israeli conflict.

Indeed, when Israeli and Jordanian military officers first drew the Green Line in 1949, Israel?s Moshe Dayan sought to preserve Batir?s unique tradition by leaving the frontier open and allowing Palestinian villagers access to lands within the newly formed Israeli state.

That 64-year-old recognition and the fact that villagers have refrained from attacks on Israelis despite Batir?s perch above a rail line connecting Jerusalem and Tel Aviv likely helped the village. Still, the case still isn?t settled.

Batir and the Parks Authority want an open frontier patrolled by cameras and sensors. The army, which still wants a physical barrier, has another six weeks come up with a proposal to submit for court review.

By then, it will be July and another eggplant season will be in full swing. An August aubergine festival is likely to be more celebratory than years past.

"Yes, we will have a festival," says council head Mr. Bader. "Look, they are preparing for the season."

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/k4DP0E25HZc/In-Israel-a-modern-wall-is-halted-by-ancient-terraces

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How To Select The Best Limousine Service | Oregon Attractions

Most will adore riding in limousines. It will barely be surprising since such vehicles could really provide convenience, comfort, and luxury for people. One could opt to rent one for bridal showers, weddings, and birthdays. One could get them for proms, airport transfers, and special meetings too. One will acquire great comfort in its ambient temperatures, big size, and comfortable interiors. One could enjoy varied amenities like mini bars, plasma televisions, and theater quality speakers. One will acquire their own personal chauffeur too. One will enjoy safety then. One must be cautious however in picking their limousine. One must only pick a proper deer valley limo service. Know then some nice tips on how to pick a proper company.

You should first get options. It would be ideal to get referrals from friends, relatives, or colleagues. You can get good choices from them. You can also do research. You would find various lists with the web. You should then check out each. You should ensure that they would have the right sort of credentials. They should have proper license. You should also choose only experienced companies. That is why you should ask about their length of experience. You can also get information about the company by reading testimonials, feedback, and complaints about them.

You should also check out their fleet. You should not base your decisions on fleet size. Some good companies can have small fleets, but would give you exceptional, personalized, and detailed services. You should instead check the brands, models, and sizes available. They should have something that would cater to your preferences, needs, and wants.

Great conditions should also be sported by these cars. If possible, the cars must even be checked out personally. When booking online however, only photos could be asked. The photos must be scrutinized cautiously however. Only functional, well maintained, and updated vehicles must be offered by the company. Convenience, safety, and comfort would then be ensured.

You would be getting a personal driver when you book limousine services. However, you should not just entrust your safety on anyone. You should then ask the company about their screening process. They should have criminal, personal, and drug screening processes for their drivers. Their drivers should also be trained. It would ensure that you would be driven only by expert, reliable, and professional drivers.

One must ask regarding the varied costs involved. One must know how much they will charge. Some will charge flat rates. Most will charge hourly rates. One must ask regarding discounts as well, especially if they will be hiring the car for long periods. One must properly compare costs. Ask whether prices will include gratuity already.

The company must sport proper insurance too. The model, type, and capacity of car will determine insurance coverage. One must make sure that the car they will hire will sport adequate coverage.

The company should also be available always. Most events, airport transfers, and needs would be beyond office hours. Emergency numbers, 24/7 dispatchers, and customer service should be available readily too.

You should consider these factors when choosing. They would help you choose the right deer valley limo service. You can then enjoy classy, safe, and luxurious limousine services without problems.

You can visit the website www.wave-transportation.com for more helpful information about How To Choose A Good Limousine Service

Source: http://oregonattractions.net/travel-leisure/how-to-select-the-best-limousine-service/

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Debt limit unlikely to be hit till after Labor Day, Treasury Secretary advises (Washington Bureau)

Share With Friends: | | Politics - Top Stories News, News Feeds and News via Feedzilla.

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Israel to authorize four West Bank settler outposts

By Maayan Lubell

JERUSALEM (Reuters) - Israel plans to declare legal four unauthorized West Bank settler outposts, a court document showed on Thursday, days before U.S. Secretary of State John Kerry returns to the region to try to restart peace talks.

Israel has been sending mixed signals on its internationally condemned settlement policy as Kerry pursues efforts to revive negotiations Palestinians quit in 2010 in anger over Israeli settlement building on occupied land they seek for a state.

In a reply to a Supreme Court petition by the Israeli anti-settlement group Peace Now, the government said it had taken steps in recent weeks to authorize retroactively four West Bank outposts built without official permission.

Nabil Abu Rdainah, a spokesman of Palestinian President Mahmoud Abbas, condemned the move.

"Israel continues to put obstacles and to sabotage U.S. efforts to resume negotiation," he said. "Our position is clear and that is all settlement is illegal and must be stopped."

A spokesman for Prime Minister Benjamin Netanyahu declined to comment on the government's response to the Supreme Court.

Most the world deems all Israeli settlements in the West Bank, which Israel captured in the 1967 Middle East war, as illegal. Israel disputes this and distinguishes between about 120 government-authorized settlements and dozens of outposts built by settlers without permission.

Peace Now said in a statement that "The intention to legalize outposts as new settlements is no less than a slap in the face of Secretary Kerry's new process and is blatant reassurance to settler interests."

Last week, Peace Now and Israeli media reports said Netanyahu has been quietly curbing some settlement activity by freezing tenders for new housing projects, in an apparent effort to help the U.S. drive to renew peace talks.

But Peace Now said at the time construction already under way was continuing, and Israel announced last week that it had given preliminary approval for 300 new homes in Beit El settlement as part of a plan Netanyahu announced a year ago.

Kerry, due to meet Netanyahu and Abbas separately next week, has said he believes "the parties are serious" about finding a way back into talks.

The main issues that would have to be resolved in a peace agreement include the borders between Israel and a Palestinian state, the future of Jewish settlements, the fate of Palestinian refugees and the status of Jerusalem.

Some 500,000 Israelis have settled in the West Bank and East Jerusalem, which was also captured from Jordan in 1967. About 2.7 million Palestinians live in those areas.

(Editing by Jeffrey Heller and Alistair Lyon)

Source: http://news.yahoo.com/israel-authorize-four-west-bank-settler-outposts-085541406.html

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Runners, Maximize Running Performance with Drills . . . This Saturday

Thanks to Alpine?s running specialist,?Kristi Moore, MSPT, for this informative article. Runner?s take note! Drills can take your running to new levels.

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If you want to improve as a runner and prevent injury, you need to do more than just run.? Running drills can be a great way to help you do both.? Running drills provide dynamic flexibility, strength training specific to running, and will help to improve your running form.? What does this mean?? You become a more efficient runner with less risk of injury.? As a Physical Therapist I use drills as a way to assess how a runner moves, to see imbalances within movement, and as a way to rehabilitate runners from injury.

Dynamic flexibility is moving joints and muscles to gain active mobility, which helps you to loosen up effectively before running.? Drills often take you through a larger range of the motions you would normally do in running.? Using bigger range of motion for repetitions warms up your muscles to get ready for running.

Drills work specific muscle groups utilized in running by exaggerating motions used in running.? This leads to improved recruitment of these muscles when we need them during running.? Drills are often quick and/or powerful movements, which will train muscles to respond quickly when running and may even help to push you quicker to a finish line.

Many of the drills highlight one or more aspect of proper running form and are accentuated? through repetitive motions, thus helping you to insert it into your typical running mechanics.? A runner needs to have proper form as well as the appropriate strength and flexibility to allow their body to run without risking injury. Each individual has specific areas to work on with strengthening? and stretching exercises, but drills take it to the next level.

One example of how a drill can address these three areas is high knee skipping.? This drill is a dynamic stretch for hip extensors, a strengthening exercise for calf muscles and quadriceps, and it improves your form by having you push off your foot closer to the mid/fore foot instead of striking with your heel.? There are similar benefits to the majority of running drills.

To learn more about drills come to?Alpine Physical Therapy?s?Free Drills session on Saturday May 18^th?at 8:30 am?at the dirt track off the Kim Williams trail.? We will demonstrate correct form with drills, explain their purpose and have you go through some beneficial drills that will improve your running. ? The first 25 people to arrive will also get a free stainless steel water bottle.? If you have any questions please call our north clinic at (406) 541-2606.

Source: http://healthandfitness101.com/?p=3809&utm_source=rss&utm_medium=rss&utm_campaign=runners-maximize-running-performance-with-drills-this-saturday

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Dell's 1Q earnings fall 79 pct as PC sales sag

ROUND ROCK, Texas (AP) ? Dell's earnings plunged 79 percent in the latest quarter as the shift to smartphones and tablets reduced demand for the company's personal computers.

The dismal performance announced Thursday actually might work to the advantage of Dell Inc.'s board. That's because Dell's directors are trying to persuade shareholders to accept a $24.4 billion buyout offer from CEO Michael Dell and other investors. Some shareholders say the sales price of $13.65 per share is too low, but Dell's board contends it's a good deal in light of challenges facing the company.

The results for the fiscal first quarter, which ended May 3, should reinforce the board's point. At the same time, opponents of that proposal may question whether the company is deliberately finding ways to make the results look as bleak as possible in an effort to get the deal done.

A shareholder vote is supposed be held by Aug. 2. Two of Dell's largest shareholders, billionaire Carl Icahn and Southeastern Asset Management, are trying to block the sale to Michael Dell with an alternative proposal that would keep the company public traded. If Michael Dell's offer is accepted, it would end Dell's 25-year history as a publicly traded company.

Dell earned $130 million, or 7 cents per share, in the latest quarter, compared with $635 million, or 36 cents per share, a year earlier.

If not for certain items unrelated to its ongoing business, Dell said it would have earned 21 cents per share. That figure was below the average estimate of 35 cents per share among analysts polled by FactSet.

The shortfall doesn't come as a shock. Speculation that Dell missed analysts' earnings target mounted earlier this week after the Round Rock, Texas, company disclosed that it would release its results ahead of schedule. The report originally was supposed to be released next Tuesday.

Dell's revenue for the period dipped 2 percent to $14.1 billion, about $600 million above analyst predictions.

The company benefited from an improvement in business software and other technology services, an area that Michael Dell wants to expand. Revenue in that business rose 12 percent from last year.

But as the world's largest seller of PCs, Dell's business still revolves around laptop and desktop machines, which are going out of style as more people embrace smartphones and tablets. Dell's revenue in its PC division dropped 9 percent in the latest quarter.

Dell's stock shed 6 cents in extended trading to $13.37.

Source: http://news.yahoo.com/dells-1q-earnings-fall-79-pct-pc-sales-202403670.html

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House Republicans repeal Obamacare again. Why do they keep doing it?

House Republicans booked yet another chapter of their drive to repeal President Obama?s signature health-care law on Thursday night, ramming their fourth complete repeal and 37th elimination of some portion of the law through the chamber on a 229-to-195 vote.

Two Democrats joined Republicans in voting for a measure that represents a cornerstone of the Republican attack on Mr. Obama and congressional Democrats in the election cycle to come.

While the scandals currently roiling Washington ? from the IRS?s overreach to the Department of Justice?s seizing of Associated Press phone records to a lack of clarity over the Obama administration?s response to the terror attacks in Benghazi, Libya ? don?t seem to have a common theme, Republicans see a unifying thread: government overreach.

RECOMMENDED: How much do you know about health-care reform? Take our quiz!

Republicans argue, in effect, this is what happens when you put your faith in big government. And at the bedrock of that critique, the purest form of this governmental overreach in the minds of many conservatives, is Obama?s signature health-care law.

Sen. Marco Rubio (R) of Florida put it just so on the Senate floor on Wednesday.

?This same IRS [who targeted conservative groups for more scrutiny] will now have unfettered power to come after every American and ensure that either you?re buying insurance or you?re paying them a tax. Every American business. The front lines of enforcing Obamacare falls to the IRS. That is what happens when you expand the scope and power of government,? Senator Rubio said.

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?It?s always sold as a noble concept. It?s always offered up by government as, ?We?re going to give the government more power so they can do good things for us.? But the history of mankind proves that every time a government gets too much power, it almost always ends up using it in destructive ways against the personal liberties of individuals,? he continued.

The health-care law is such a fundamental piece of the Republican political playbook because it has enormous implications for the lives of ordinary Americans ? and thus weighty political implications.

Republicans have argued for a long, long time that excluding a handful of popular provisions in the health-care law, the implementation of the bulk of the law regarding insurance exchanges in late 2013 and 2014 will be a disaster. That?s because, they argue, the law is too complex and dysfunctional to be well-implemented, Republicans argue, and will drive up insurance costs with little accompanying benefit.

?Ultimately, that?s the meaning of the vote being taken by the House of Representatives on Thursday,? said Joe Trauger, a vice president at the National Association of Manufacturers, in an e-mailed statement. ?It is a vote of no-confidence.?

Americans tend to agree that the law will drive up premiums, according to a recent survey by TIPP/The Christian Science Monitor. Some 61 percent say that premiums will increase significantly versus 7 percent who think they will stay the same and 25 percent who think premiums will drop significantly.

Republicans have had some policy impact on the law already. On seven occasions, bills specifically targeting the health-care law or changes to the law folded into other bills have passed the House and been signed by the president.

Republicans think it?s such a bad deal, in fact, that they?re willing to overlook something that usually stops bill dead in its tracks ? the fact that repealing the law adds to the deficit. When the Congressional Budget Office looked at the impact of repealing the law in July 2012, it concluded that such legislation would add just over $100 billion to the deficit over the next decade.

They also see a political benefit. Senate Republicans? campaign committee targeted Democratic Reps. Bruce Braley of Iowa and Gary Peters of Michigan, two 2014 Senate contenders, with statements challenging them to vote to repeal the health-care law, for example.

Conservatives remember the 2010 midterms, when rage about the health-care law helped them give congressional Democrats a ?shellacking,? in the president?s words, and put Republicans into the majority in the House. It?s that 2010 election ? and to a lesser extent the 2012 polls ? that force the GOP to hold votes on the issue.

The Monitor/TIPP poll shows the public is split on the law, with 46 percent saying the law should be repealed in full but roughly the same share of Americans saying the bill should either be expanded or left as-is (21 and 24 percent, respectively).

However, momentum may be in the GOP's favor. Forty percent of Americans view the health-care law more negatively than they did one year ago, according to the poll, compared with 10 percent who view the law more favorably. A slim majority, 51 percent, oppose the law either somewhat or strongly, while 39 percent support the law in some fashion.

But the law is a lightning rod with the conservative base, and conservative lawmakers are concerned about appearing to go soft on the issue.

Several members on the GOP conference?s most rightward flank objected to voting for a GOP proposal that aimed to shift funds from one part of the law to another last month, arguing that because the conference had not yet voted to repeal the entire law yet. Republicans didn't want to appear to be validating the law by tweaking it before voting to rip it out by the roots once again.

Those conservative concerns didn?t appear to be misplaced on Thursday: The base is certainly paying close attention.

Obamacare was not far from the lips of tea party activists protesting the IRS?s targeting of conservative groups on Capitol Hill.

?When you think about Obamacare being implemented and 16,000 more people added to the IRS, are they going to be next determining who can get health care based on your political views?? asked Dianne Belsom, a leader of a South Carolina tea party group.

As such, the 37th vote almost certainly won?t be the last.

?Many people have said this issue was dead. Many people have said that Obamacare is here to stay. We are here as the people's representatives, as real people from across the United States, to say this issue is now revived,? said Rep. Michelle Bachmann (R) of Minnesota, the sponsor of the health-care repeal law. ?It is back on the table.?

RECOMMENDED: How much do you know about health-care reform? Take our quiz!

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Source: http://news.yahoo.com/house-republicans-repeal-obamacare-again-why-keep-doing-231730585.html

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My View Of The Duke Game - Card Chronicle

Pretty good seats.

So I didn't really talk about this at the time, but as part of reliving March and April, one of the more complex set of memories is the Duke game. Not just because of what happened, but because until that moment it was the best, most surreal game watching experience I had ever had. Oh, and now I will forever be enshrined in VillenHD and CrumsRevenge videos. Here we go.

I have some ticket connections but they are mostly good for when people I know with good tickets don't want to go to the games. I have season tickets in the upper level, but I buy those through someone. I have little to no "points" and I think I'd probably have to give my real name if I ever applied for a press pass (although one with CardsFan922 on it would be pretty awesome) and I doubt I'd get one either way. I don't mind spending a little money on stubhub to ensure I get into the arena, and avoid outside, game-day scalping at all costs. But I'm not springing for the really expensive tickets. Honestly, I prefer sitting by myself at games, and my wife usually would prefer I sit by myself if she had someone more reasonable to sit with, but usually she is stuck with me. All of this is to say, my tickets for Friday night's game were really good, but not great: sideline view, but up high and a little behind the basket:

My wife went to that game, but we knew if we won Sunday's game would be Easter. And that there was no way she was going, and no way I wasn't going. I was still able to do some family stuff, I would just have to leave early. No big deal. My brother would go with me to Sunday's game, and we were pumped.

So late Saturday night, I get a text...yadda yadda yadda friend of a friend who I also know and my brother also knows really well (because Louisville is a small town) has 2 seats "4 rows behind the bench." At a very, very reasonable price, especially after I unloaded my seats for face value to someone else, and didn't have to pay stubhub fees. Now, the person who told me about the seat location has a history of not being precise on such things, so I did not really expect 4 rows behind the bench. But I figured they would be an upgrade.

And then we got there:

Ya. So that's the UofL bench, two rows of seats, a walkway and then we were in the second row. We got there about an hour early, and basically just stood there in awe the entire time. I think I may have even offered the guys we were with more money beyond what I paid. Big Russ walked by, came over and talked to us. Told us the team was locked in, everyone's health was good, everyone was ready. Jurich stood about 5 feet away, alone, the whole time, but none of us approached him. Charlie Strong, the Pitino family a section over, walk on players who didn't dress (I think it was Slime and Mangok?), all passed by us over and over. It was surreal, and awesome and the most amazing thing ever.

Here is our team warming up:

Here they are getting ready for the starting lineups:

So basically during the game, I'm trying to be on my best behavior, not yell at the refs like I normally do, not yell "EAT HIM UP HENDO" everytime Hendo guards someone (did this in second half though), etc. (Note: I never, ever yell bad things at our players or opposing players, and therefore all of my energy goes towards the refs. They are the only adults out there. One time I wanted to yell at Jamie Dixon that he had ruined college basketball but I was with someone who would never invite me back if I did, so I thought better of it.)

Anyway, trying to follow the action from a vantage point I'm not familiar with is tough, as was trying to also keep an eye on the bench to see the little things you normally don't see during the games, and sorta follow Twitter although that was too much, and hey look there's Charlie Strong. There was a lot going on.

Then, Kevin Ware. I saw Ware closing out really fast, followed the ball as it went in and then looked back and saw Pitino waiving his arms. I looked down and saw bone. I spun around as fast as I could and put my head in my hands and tweeted something along the lines of "that's the worst thing I've ever seen." It was so quiet, I thought I maybe heard moaning, but I wasn't sure. I did not turn around. Once he was covered up, I maybe turned around for a split second and vaguely remember seeing our guys on the court. But all of the video of guys crying, people throwing up, etc., I did not see any of that even though I was so close. I don't remember everything.

So after that, getting to halftime was the longest 6 minutes of the season. You could just feel the energy sucked out. Ball goes in? Good, but really let's not get that excited because does it even matter?. Duke scores? Whatever. Hard to care. Couldn't help but feeling, hey, it's just a game with a ball. I had gone from enjoying the best seats I had ever experienced in the biggest game of the season, to...I don't even know how to describe how all of us were feeling, because I think everyone around me felt the same way. And everyone watching at home.

At halftime, I was this close to Goodman interviewing Richard, but really wasn't in the mood to joke about prizes or Gorgui or twitter or anything:

The second half, I mean, I don't even know. It was just as surreal as everything else was that day. Because of the vantage point and the emotional exhaustion and just the overwhelming experience overall, I did not really understand or appreciate the lead we were building. When Duke tied it, and then either Russ or Siva got his 3rd foul, I was close enough to see an assistant tell Pitino it was a guard's 3rd foul, see him look to spot on bench where Kevin Ware should have been, realize why he wasn't there, then look down and mutter some profanities to himself. It was a small moment and ultimately meaningless in the outcome, but it is one I will never forget. Then, Hendo.

At some point I looked up and it was a double digit lead. And then 12 points, then like 16, and that can't be right? This is Duke in the Elite 8? We have made like one 3 pointer. What is happening here? At one point, Duke called timeout and Chane looked up into the crowd and put both hands up into the air and made the #1 sign, nodding his head and smiling. My brother swore Chane was looking directly at him, and started nodding only when my brother started nodding.

Then at some point late in the game, you just sorta realized what had just happened. The people cheering for Duke right around us left. It was just UofL fans and it was a weird euphoria and dread and relief and all those feelings. Then I noticed Chane doing something. Whose jersey is that?

After the game we hung around for awhile. Didn't want to leave. The whole thing was....maybe this is why the Paul Rogers call at the end of the @CrumsRevenge video gets me every time.

Pretty incredible, indeed.

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Source: http://www.cardchronicle.com/2013/5/15/4334028/my-view-of-the-duke-game

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Chemists demonstrate nanoscale alloys so bright they could have potential medical applications

May 14, 2013 ? Alloys like bronze and steel have been transformational for centuries, yielding top-of-the-line machines necessary for industry. As scientists move toward nanotechnology, however, the focus has shifted toward creating alloys at the nanometer scale -- producing materials with properties unlike their predecessors.

Now, research at the University of Pittsburgh demonstrates that nanometer-scale alloys possess the ability to emit light so bright they could have potential applications in medicine. The findings have been published in the Journal of the American Chemical Society.

"We demonstrate alloys that are some of the brightest, near-infrared-light-emitting species known to date. They are 100 times brighter than what's being used now," said Jill Millstone, principal investigator of the study and assistant professor of chemistry in Pitt's Kenneth P. Dietrich School of Arts and Sciences. "Think about a particle that will not only help researchers detect cancer sooner but be used to treat the tumor, too."

In the paper, Millstone presents alloys with drastically different properties than before -- including near-infrared (NIR) light emission -- depending on their size, shape, and surface chemistry. NIR is an important region of the light spectrum and is integral to technology found in science and medical settings, said Millstone. She uses a laser pointer as an example.

"If you put your finger over a red laser [which is close to the NIR light region of the spectrum], you'll see the red light shine through. However, if you do the same with a green laser [light in the visible region of the spectrum], your finger will completely block it," said Millstone. "This example shows how the body can absorb visible light well but doesn't absorb red light as well. That means that using NIR emitters to visualize cells and, ultimately parts of the body, is promising for minimally invasive diagnostics."

In addition, Millstone's demonstration is unique in that she was able to show -- for the first time -- a continuously tunable composition for nanoparticle alloys; this means the ratio of materials can be altered based on need. In traditional metallurgical studies, materials such as steels can be highly tailored toward the application, say, for an airplane wing versus a cooking pot. However, alloys at the nanoscale follow different rules, says Millstone. Because the nanoparticles are so small, the components often don't stay together and instead quickly separate, like oil and vinegar. In her paper, Millstone describes using small organic molecules to "glue" an alloy in place, so that the two components stay mixed. This strategy led to the discovery of NIR luminescence and also paves the way for other types of nanoparticle alloys that are useful not only in imaging, but in applications like catalysis for the industrial-scale conversion of fossil fuels into fine chemicals.

Millstone says that taken together these observations provide a new platform to investigate the structural origins of small metal nanoparticles' photoluminescence and of alloy formation in general. She believes these studies should lead directly to applications in such areas of national need as health and energy.

Funding was provided by the University's Central Research Development Fund and administered by Pitt's Office of Research and University Research Council.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/JLT1it0AWBY/130514122803.htm

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Rock The Bells To Reincarnate Ol' Dirty Bastard, Eazy-E

10th anniversary of the rap festival will feature hologram performances from icons along with Tyler, the Creator and Rakim.
By Gil Kaufman

Source: http://www.mtv.com/news/articles/1707356/rock-the-bells-2013-lineup-holograms.jhtml

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Inconvenient Deficit Facts (talking-points-memo)

Share With Friends: | | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/305785375?client_source=feed&format=rss

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Read and write flashdrive for your iPad and other iOS devices

Apple’s Camera Connection Kit will let you transfer photos to your iPad, but it doesn’t allow you to copy files off the iPad. ?It handles several image and video file formats, but nothing else. ?With The Only Read and Write iPad Flash Drive from Hammacher Schlemmer, you can, as you might guess, both read and [...]

Source: http://the-gadgeteer.com/2013/05/14/read-and-write-flashdrive-for-your-ipad-and-other-ios-devices/

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Sony Xperia SP review: lights, camera, performance

Sony's Xperia Z took the company into the big leagues this year: the company finally has a handset that turns heads and can compete with the established Galaxy and One brands. The Z and its plainer ZL variant weren't the only bullets in the Xperia revolver for 2013, though. Back in March, the company announced the Xperia SP and Xperia L handsets to fall in line behind its flagship. While the L is undoubtedly targeted at the low end of the Android spectrum, the Xperia SP sits in a strange middle ground, with a 720p display and internals that rival the flagships of 2012. It's not some kind of Xperia S and P fusion, either. The design is vastly different from the sum of its moniker, although the transparent element that defined those devices makes a comeback here.

And thus, with intrigue, we must put the Xperia through its paces the Engadget way. Is it just another Android handset put out so there's something with the Sony name available at a lower price point than the Z? Is there anything other than a transparent piece of plastic to set it apart from the plethora of other touchscreen rectangles that live in the shadow of their top-tier peers? Instead of pondering the answers to those questions yourself, save time by heading past the break for our full review.

Gallery: Sony Xperia SP review

Filed under: Cellphones, Mobile, Sony

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/k6Z7gIsoDjU/

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